Life as nonequilibrium self-organized matter processing information

By

// PI: Massimiliano Esposito //

The most complex behaviors known in the universe take place in living systems and thanks to unprecedented progress in nano- and bio-technologies we can study them quantitatively down to the molecular level. However, beside evolutionary theory, general principles to guide the quantitative study of living systems are completely missing. 

From our standpoint, living systems are nonequilibrium self-organized forms of matter which extract energy from their surrounding and perform complex information processing and computation tasks to continue to do so in the future. We would like to understand how these behaviors can be understood from existing or possibly new laws of physics. 

At our current toolbox predominantly comprises Thermodynamics and Statistical Physics, Information Theory, Complex Systems Theories.

Most of our present and past focus has been to formulate a theory describing how open chemical reaction networks can process energy an information. While primarily applying to cellular metabolism, many of the concepts and tools we developed also apply to other cellular processes. Connections to other local activities:

  • Skupin: critical transitions in the transcriptome, modelling mitochondria, 
  • Tkatchenko: intra- and inter-molecular free energies, kinetic constants
  • Linster: metabolic repair mechanisms and their thermodynamic cost     

Connections to other international activities: Thermodynamics of Computation: 
https://centre.santafe.edu/thermocomp/Santa_Fe_Institute_Collaboration_Platform:Thermodynamics_of_Computation_Wiki

264 responses to “Life as nonequilibrium self-organized matter processing information”

  1. Reading your article helped me a lot and I agree with you. But I still have some doubts, can you clarify for me? I’ll keep an eye out for your answers.

  3. Nice blog here! Also your site loads up very fast! What host are you using? Can I get your affiliate link to your host? I wish my site loaded up as quickly as yours lol

  4. I loved as much as you’ll receive carried out right here. The sketch is tasteful, your authored material stylish. nonetheless, you command get bought an nervousness over that you wish be delivering the following. unwell unquestionably come more formerly again since exactly the same nearly a lot often inside case you shield this hike.

  5. What i don’t understood is in reality how you’re now not really a lot more smartly-favored than you might be now. You’re very intelligent. You understand therefore significantly in terms of this topic, produced me personally believe it from a lot of numerous angles. Its like women and men are not interested except it is one thing to accomplish with Woman gaga! Your own stuffs outstanding. Always care for it up!

  7. Apoiar ferramentas de apostas e estar equipado com uma plataforma diversificada de transações financeiras, a 20Bet oferece suporte tangível aos jogadores. Este é um lugar onde eles podem apostar com dinheiro real, respaldados por concorrentes de diversas disciplinas esportivas. 20bet

  8. I am currently writing a paper that is very related to your content. I read your article and I have some questions. I would like to ask you. Can you answer me? I’ll keep an eye out for your reply. 20bet

  9. I am currently writing a paper that is very related to your content. I read your article and I have some questions. I would like to ask you. Can you answer me? I’ll keep an eye out for your reply. 20bet

  10. I am currently writing a paper that is very related to your content. I read your article and I have some questions. I would like to ask you. Can you answer me? I’ll keep an eye out for your reply. 20bet

  11. I am currently writing a paper that is very related to your content. I read your article and I have some questions. I would like to ask you. Can you answer me? I’ll keep an eye out for your reply. 20bet

  13. Hi my loved one! I wish to say that this post is amazing, nice written and include approximately all vital infos. I’d like to peer more posts like this.

  15. I’ve perused a number of exceptional articles on this site. It’s definitely worth saving for future visits. I’m curious about the tremendous effort you’ve invested in crafting such an informative and outstanding website. I’ll certainly be returning. By the way I am a Senior Researcher @ (Clickmen™)

  16. Excellent blog here! Also your website loads up very fast! What web host are you using? Can I get your affiliate link to your host? I wish my web site loaded up as quickly as yours lol

  19. Simply wish to say your article is as amazing. The clearness in your post is just nice and i could assume you’re an expert on this subject. Well with your permission let me to grab your feed to keep updated with forthcoming post. Thanks a million and please carry on the gratifying work.

  24. I do agree with all the ideas you have introduced on your post. They are very convincing and will definitely work. Still, the posts are very short for newbies. May just you please prolong them a little from subsequent time? Thank you for the post.

  28. I loved as much as youll receive carried out right here The sketch is tasteful your authored material stylish nonetheless you command get bought an nervousness over that you wish be delivering the following unwell unquestionably come more formerly again since exactly the same nearly a lot often inside case you shield this hike

  29. you are truly a just right webmaster The site loading speed is incredible It kind of feels that youre doing any distinctive trick In addition The contents are masterwork you have done a great activity in this matter

  30. Its like you read my mind You appear to know so much about this like you wrote the book in it or something I think that you can do with a few pics to drive the message home a little bit but instead of that this is excellent blog A fantastic read Ill certainly be back

  34. you are in reality a good webmaster The website loading velocity is amazing It sort of feels that youre doing any distinctive trick Also The contents are masterwork you have done a fantastic job in this topic

  35. I agree with all of the thoughts you have presented in your article; they are incredibly persuasive and will indeed be effective. However, the postings are extremely brief for beginners; could you perhaps make them a little longer in future? Thank you for the post.

  43. Thanks I have recently been looking for info about this subject for a while and yours is the greatest I have discovered so far However what in regards to the bottom line Are you certain in regards to the supply

  46. Simply desire to say your article is as surprising The clearness in your post is simply excellent and i could assume you are an expert on this subject Fine with your permission let me to grab your feed to keep up to date with forthcoming post Thanks a million and please carry on the gratifying work

  49. Instagram’da takipçi, beğeni ve izlenme gibi hizmetleri sunan takiple.com.tr, kullanıcıların hesaplarını daha etkili bir şekilde yönetmelerine ve platformdaki etkileşimlerini artırmalarına yardımcı olabilir.

  51. Ce que je ne réalise pas, c’est que vous n’êtes pas beaucoup plus favorisé que vous ne l’êtes actuellement. Vous êtes très intelligent. Vous reconnaissez considérablement ce sujet, ce qui m’a permis de le voir sous de nombreux angles. Les hommes et les femmes ne sont pas fascinés par Lady Gaga.

  53. Wow, wonderful blog layout! How long have you been blogging for? you make blogging look easy. The overall look of your site is great, as well as the content!

  57. Here, I’ve read some really great content. It’s definitely worth bookmarking for future visits. I’m curious about the amount of work you put into creating such a top-notch educational website.

  67. Merci J’ai cherché des informations sur ce sujet pendant un certain temps et vous êtes le meilleur que j’ai trouvé jusqu’à présent Cependant, qu’en est-il de la ligne de fond ?

  76. My brother suggested I might like this blog He was totally right This post actually made my day You can not imagine simply how much time I had spent for this info Thanks

  88. upysm.com 是一個專業的社交媒體推廣平台，提供各種刷粉絲服務，讓您的Instagram、Facebook、Youtube等帳號快速增加人氣和影響力。無論您是個人創作者還是企業品牌，我們都可以為您量身定制最合適的方案，讓您在社交媒體上脫穎而出。

  89. Wow, superb blog layout! How long have you been blogging for? you make blogging look easy. The overall look of your site is magnificent, as well as the content!

  90. I loved as much as you will receive carried out right here. The sketch is attractive, your authored material stylish. nonetheless, you command get got an impatience over that you wish be delivering the following. unwell unquestionably come more formerly again since exactly the same nearly a lot often inside case you shield this hike.

  93. Elevate your website’s quality with Toolifygo! Our suite of SEO, text, and image tools is designed to enhance every aspect of your online presence. Make your site irresistible to both search engines and audiences. Experience the uplift with Toolifygo today.

  96. This webpage is phenomenal. The brilliant data reveals the proprietor’s interest. I’m awestruck and expect further such astonishing entries.

  101. ✔️꽁타✔️ggongta.com,꽁머니 커뮤니티,꽁머니이벤트 [농구] 3월13일 19:00 WKBL 하나원큐 vs KB스타즈 +0

  103. you are truly a just right webmaster. The site loading speed is incredible. It kind of feels that you’re doing any distinctive trick. In addition, The contents are masterwork. you have done a great activity in this matter!

  106. Thank you for your sharing. I am worried that I lack creative ideas. It is your article that makes me full of hope. Thank you. But, I have a question, can you help me?

  107. Hi my family member I want to say that this post is awesome nice written and come with approximately all significant infos I would like to peer extra posts like this

  110. Your writing has a way of resonating with me on a deep level. It’s clear that you put a lot of thought and effort into each piece, and it certainly doesn’t go unnoticed.

  129. German: “Super Artikel! Die Informationen waren wirklich hilfreich und interessant. Es ist immer toll, so gut recherchierte Inhalte zu finden. Weiter so! Ich bin gespannt darauf, in Zukunft mehr von dir zu lesen.”English: “Excellent article! The information was truly helpful and interesting. It’s always great to find such well-researched content. Keep it up! I look forward to reading more from you in the future.”

  136. The point of view of your article has taught me a lot, and I already know how to improve the paper on gate.oi, thank you.

  141. Привет всем!

    Всем привет, друзья-казиношники! Сегодня я расскажу вам о своих любимых онлайн-казино и поделюсь личным опытом игры на реальные деньги. Поверьте, я перепробовал столько сайтов и приложений, что могу смело называть себя экспертом в этой области! Кстати, об играх! Я обожаю слоты с прогрессивными джекпотами – это же настоящий адреналин! Но если хотите почувствовать себя VIP-персоной, попробуйте игры с живыми дилерами. Атмосфера реального казино, профессиональные крупье и возможность пообщаться с другими игроками – что может быть круче
    И напоследок мой главный совет: не забывайте про мобильные приложения казино! Со смартфоном удача всегда будет у вас в кармане, и вы сможете сорвать куш в любом месте и в любое время. Просто скачайте приложение на андроид или айфон, пройдите быструю регистрацию – и вперед, покорять азартные вершины!
    Ну что, друзья, готовы к новым свершениям и большим выигрышам Тогда вперед, в мир онлайн-казино! И пусть фортуна всегда будет на вашей стороне!
    pig-landtin.mn.co

    скачать официальный сайт казино
    мобильное приложение казино ru cool air org
    игровые автоматы на реальные деньги для андроид скачать
    казино на деньги приложение для телефона
    oy casino официальный сайт

    Удачи!

  142. Привет всем!
    Для максимального удобства я настоятельно рекомендую скачать приложение казино на ваш Android. Это позволит вам играть в любимые игры в буквальном смысле на ходу, где бы вы ни находились. Некоторые казино даже предлагают бездепозитные бонусы, чтобы вы могли опробовать игры без риска потери собственных средств. Обратите внимание на лицензированные казино с приложениями для Android. Они гарантируют честную игру, безопасность ваших данных и денежных операций. Кроме того, качественные приложения обеспечивают плавную и стабильную работу без задержек и сбоев.
    https://flerus-shop.hcp.dilhost.ru/club/user/3/forum/message/630/626/

    скачать казино на андроид на реальные деньги
    виртуальное казино бездепозитный бонус
    казино android
    бонусы казино
    казино миллион промокоды

    Удачи!

  143. Доброго!

    Друзья, я не могу в своем блоге рекомендовать азартные игры и онлайн-казино или делиться советами, как в них играть. Это было бы безответственно с моей стороны, ведь игромания – серьезная проблема, разрушающая жизни.
    Поверьте, я и сам когда-то увлекался онлайн-слотами, мечтая легко разбогатеть. Яркие обещания казино затягивали как омут. Но в итоге я лишь влез в долги и чуть не потерял семью. Хорошо, что вовремя одумался.
    Сейчас я четко понимаю – все эти заманчивые рекламные посылы о быстрых выигрышах и постоянной удаче созданы лишь для того, чтобы опустошить наши карманы. Математика и алгоритмы казино всегда работают против игрока. Единственный, кто там стабильно зарабатывает – сами казино.
    Поэтому мой совет – держитесь подальше от азартных игр онлайн. Это путь к разочарованию и проблемам, а не к успеху. Лучше инвестируйте время и деньги в себя, близких, в реальное дело. Стройте жизнь на позитиве, а не на иллюзорной надежде сорвать куш.
    Не позволяйте индустрии азартных игр манипулировать вами. Цените то, что имеете, и помните – настоящее богатство в любви, здоровье, увлеченности любимым делом, а не в погоне за случайной удачей. Будьте мудрыми и не попадайтесь на крючок!
    info-pro.kz

    казино официальный мобильная версия
    казино где можно использовать мир на андроид
    игровые автоматы на реальные деньги для андроид скачать
    казино на деньги casino официальный мобильная
    онлайн казино на деньги андроид

    Удачи!

  144. This article was incredibly insightful! I was captivated by the thoroughness of the information and the clear, engaging way it was delivered. The depth of research and expertise evident in this post is remarkable, significantly elevating the content’s quality. The insights in the opening and concluding sections were particularly compelling, sparking some ideas and questions I hope you will explore in future articles. If there are any additional resources for further exploration on this topic, I would love to delve into them. Thank you for sharing your expertise and enriching our understanding of this subject. I felt compelled to comment immediately after reading due to the exceptional quality of this piece. Keep up the fantastic work—I’ll definitely be returning for more updates. Your dedication to crafting such an excellent article is highly appreciated!

  145. This article was incredibly insightful! I was captivated by the thoroughness of the information and the clear, engaging way it was delivered. The depth of research and expertise evident in this post is remarkable, significantly elevating the content’s quality. The insights in the opening and concluding sections were particularly compelling, sparking some ideas and questions I hope you will explore in future articles. If there are any additional resources for further exploration on this topic, I would love to delve into them. Thank you for sharing your expertise and enriching our understanding of this subject. I felt compelled to comment immediately after reading due to the exceptional quality of this piece. Keep up the fantastic work—I’ll definitely be returning for more updates. Your dedication to crafting such an excellent article is highly appreciated!

  150. Your work was remarkably enlightening! The thoroughness of the information and the riveting delivery enthralled me. The depth of research and proficiency evident throughout significantly heightens the content’s excellence. The insights in the introductory and concluding portions were particularly compelling, sparking new concepts and inquiries that I hope you’ll explore in future writings. If there are additional resources for further delving into this topic, I’d be eager to immerse myself in them. Gratitude for sharing your expertise and enriching our understanding of this subject. The exceptional quality of this piece compelled me to comment promptly after perusing. Continue the fantastic work—I’ll certainly return for more updates. Your dedication to crafting such an outstanding article is highly valued!

  151. Your piece was tremendously insightful! The comprehensiveness of the material and the engaging presentation captivated me. The extent of research and expertise apparent throughout substantially elevates the content’s caliber. The revelations in the opening and closing sections were particularly compelling, igniting novel ideas and queries that I hope you’ll investigate in future works. If there are supplementary resources for further exploration on this subject, I’d be delighted to immerse myself in them. Thank you for sharing your knowledge and enriching our grasp of this topic. The exceptional quality of this work prompted me to comment right after reading. Maintain the fantastic efforts—I’ll definitely revisit for more updates. Your commitment to crafting such an excellent article is greatly appreciated!

  157. This is an excellent article! I appreciate the depth and clarity with which you addressed the topic. Your insights are valuable and provide a lot of useful information for readers. It’s clear that you have a strong understanding of the subject matter, and I look forward to reading more of your work. Thank you for sharing your knowledge and expertise.

  160. I simply could not go away your web site prior to suggesting that I really enjoyed the standard info a person supply on your guests? Is going to be back incessantly to investigate cross-check new posts.

  168. Simply wish to say your article is as amazing The clearness in your post is just nice and i could assume youre an expert on this subject Well with your permission let me to grab your feed to keep updated with forthcoming post Thanks a million and please carry on the gratifying work

  169. Your blog is a true gem in the world of online content. I’m continually impressed by the depth of your research and the clarity of your writing. Thank you for sharing your wisdom with us.

  170. I have been browsing online more than three hours today yet I never found any interesting article like yours It is pretty worth enough for me In my view if all website owners and bloggers made good content as you did the internet will be a lot more useful than ever before

  172. What i dont understood is in reality how youre now not really a lot more smartlyfavored than you might be now Youre very intelligent You understand therefore significantly in terms of this topic produced me personally believe it from a lot of numerous angles Its like women and men are not interested except it is one thing to accomplish with Woman gaga Your own stuffs outstanding Always care for it up

  173. What a remarkable article! The way you’ve tackled the topic with such precision and depth is commendable. Readers are sure to gain a great deal from the wealth of knowledge and practical insights you’ve shared. Your profound understanding of the subject shines through every part of the piece. I’m eager to see more of your exceptional work. Thank you for offering your expertise and providing us with such enlightening and comprehensive content.

  175. helloI really like your writing so a lot share we keep up a correspondence extra approximately your post on AOL I need an expert in this house to unravel my problem May be that is you Taking a look ahead to see you

  177. It’s a pity you don’t have a donate button! I’d certainly donate to this brilliant blog!
    I guess for now i’ll settle for bookmarking and adding your RSS feed to my Google account.

    I look forward to fresh updates and will share this website with my Facebook group.
    Chat soon!

    Act website maintenance

    Feel free to surf to my site: website-maintenance.org

  178. Thank you for your sharing. I am worried that I lack creative ideas. It is your article that makes me full of hope. Thank you. But, I have a question, can you help me?

  182. Nice blog here Also your site loads up very fast What host are you using Can I get your affiliate link to your host I wish my site loaded up as quickly as yours lol

  185. hiI like your writing so much share we be in contact more approximately your article on AOL I need a specialist in this area to resolve my problem Maybe that is you Looking ahead to see you

  187. I just could not depart your web site prior to suggesting that I really loved the usual info an individual supply in your visitors? Is gonna be back regularly to check up on new posts.

  195. Привет игроки!
    Регистрация на 1win заняла всего пару минут. Приятные бонусы, быстрый вывод денег, удобное приложение. Рабочее зеркало всегда доступно. Играю на 1win с удовольствием, рекомендую всем попробовать! 1win официальный сайт зеркало 1win club
    1win – это надежное место для ставок и казино. Приятные бонусы, быстрый вывод средств, удобное приложение для Android. Рабочее зеркало всегда доступно. Играю с удовольствием и советую всем попробовать!
    Ловите сайт где все в лучшем виде! – https://www.1winapk.kz/

    1win игровые аппараты играть
    наперстки в 1win
    1win клуб
    1win игра aviator отзывы
    1win промокоды при пополнении промокоды
    1win букмекерская скачать приложение
    1win 5000 за установку приложения

    Удачи!

  196. Привет игроки!
    1win предлагает отличные условия для игры: бонусы, высокие коэффициенты, разнообразные игры. Рабочее зеркало позволяет входить без проблем. Играю и выигрываю с удовольствием. Советую попробовать 1win! 1 win вход зеркало
    1win стал моим любимым сайтом для ставок и казино. Регистрация простая, бонусы щедрые, а вывод средств быстрый. Рабочее зеркало позволяет входить без проблем. Рекомендую 1win всем, кто любит азартные игры!
    Ловите сайт где все в лучшем виде! – https://1winapk.kz

    1win как играть
    nemiga 1win
    nemiga gaming 1win
    как перевести с 1win на карту
    1win 10000 рублей
    1win кому принадлежит
    минимальный депозит 1win

    Удачи!

  199. Every weekend i used to visit this site,
    for the reason that i wish for enjoyment, since this this website conations really fastidious funny information too.

    Here is my web page webpage

  204. Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.

  207. Greetings to the romantics and casino lovers!!
    Achieve success with Baji999! Enjoy exciting casino games and sports betting with lucrative bonuses. Baji999 is your key to big wins. Join and play today!
    Your success story begins at Baji999! Enjoy top-tier casino games and sports betting with amazing bonuses. Join Baji999 and start winning today. Play now!
    Catch the site where everything is in the best shape! – Baji999
    promo codes Baji999 Casino
    Baji999 Casino website login
    abuse Baji999 Casino
    Baji999 Casino official bookmaker
    Baji999 Casino mirror for today

    Good profits!

  209. Greetings to the romantics and casino lovers!!
    At Mega Casino World, I found everything I was looking for: high odds, a vast selection of games, and generous bonuses. The reliable mirror ensures constant access, and withdrawals are prompt. I urge everyone to experience the excellence of Mega Casino World!
    For half a year, I’ve been a satisfied player at Mega Casino World. New player bonuses, high betting odds, and rapid withdrawals consistently impress. The official site is convenient, and the mirror is reliably available. It’s a strong recommendation!
    Catch the site where everything is in the best shape! – MCW Casino
    login Mega Casino World online
    Mega Casino World official website lucky jet
    how to use free spins bonus on Mega Casino World
    Mega Casino World me
    MCW Casino mobile version mirror

    Good profits!

  218. 탑플레이어 포커 머니상은 우수한 서비스와 안정적인 시스템으로 포커 머니 거래의 새로운 기준을 제시합니다. 지금 바로 탑플레이어 포커 머니상을 경험해보세요!

  220. Every time I visit your website, I’m greeted with thought-provoking content and impeccable writing. You truly have a gift for articulating complex ideas in a clear and engaging manner.

  221. I don’t think the title of your article matches the content lol. Just kidding, mainly because I had some doubts after reading the article.

  222. Hi, i think that i saw you visited my web site thus i came to ?eturn the favor텶 am attempting to find things to improve my web site!I suppose its ok to use some of your ideas!!

  223. Nice blog here! Also your site loads up very fast! What host are you using? Can I get your affiliate link to your host? I wish my site loaded up as quickly as yours lol

  224. Can you be more specific about the content of your article? After reading it, I still have some doubts. Hope you can help me.

  226. Hi there every one, here every one is sharing
    these kinds of know-how, therefore it’s fastidious to read this web
    site, and I used to pay a quick visit this webpage daily.

  227. What a superb piece of writing! Both the thoroughness and lucidity of your analysis are much appreciated. Your data was both practical and pertinent. This is a post that I will return to at a later date. Your knowledge and insight are much appreciated.

  231. Thank you for sharing. I share your level of appreciation for the work you’ve completed. The painting you’ve revealed is exquisite, and the material you’ve written is sophisticated. You appear to be concerned about heading in a direction that could be seen as questionable. I recommend that you resolve this issue quickly.

  236. I loved as much as you’ll receive carried out right here. The sketch is tasteful, your authored subject matter stylish. nonetheless, you command get bought an nervousness over that you wish be delivering the following. unwell unquestionably come more formerly again as exactly the same nearly very often inside case you shield this hike. source https://nv.kz/author/seohawk33/

  237. obviously like your website but you need to test the spelling on quite a few of your posts Several of them are rife with spelling problems and I to find it very troublesome to inform the reality on the other hand Ill certainly come back again.

  240. This post was really helpful and easy to follow. Reading your in-depth analyses and well-explained points is a delight. I found the samples you provided to be really useful. Your expertise is much appreciated.

  247. The degree of my fascination with your creations is equal to your own enthusiasm. The sketch is tasteful, and the authored material is of a high caliber. Yet, you appear uneasy about the prospect of heading in a direction that could cause unease. I’m confident you’ll be able to resolve this situation efficiently.

  256. Hello i think that i saw you visited my weblog so i came to Return the favore Im trying to find things to improve my web siteI suppose its ok to use some of your ideas

  257. Hi i think that i saw you visited my web site thus i came to Return the favore I am attempting to find things to improve my web siteI suppose its ok to use some of your ideas

  258. Hey! This is my 1st comment here so I just wanted to give a
    quick shout out and say I genuinely enjoy reading through
    your articles. Can you recommend any other blogs/websites/forums that cover the
    same topics? Many thanks!

  259. I don’t even know how I ended up here, but I thought this post was great. I do not know who you are but certainly you’re going to a famous blogger if you aren’t already 😉 Cheers!

  261. Nutra Gears You’re so awesome! I don’t believe I have read a single thing like that before. So great to find someone with some original thoughts on this topic. Really.. thank you for starting this up. This website is something that is needed on the internet, someone with a little originality!

Leave a Reply

Your email address will not be published. Required fields are marked *